Clinical Proteomics
Methods and Protocols
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Beschreibung
The field of clinical proteomics has rapidly evolved during the past few years and is continuously growing as new methodologies and technologies emerge. In Clinical Proteomics, a select group of leading researchers has contributed their state-of-the-art methodologies on protein profiling and identification of disease biomarkers in tissues, microdissected cells and body fluids. Experimental approaches involving the application of two-dimensional electrophoresis, multi-dimensional liquid chromatography, SELDI/MALDI mass spectrometry and protein arrays, as well as the bioinformatic and statistical tools pertinent to the analysis of proteomics data, are thoroughly detailed in these readily reproducible methods and protocols, explained through the step-by-step instructional format of the highly successful Methods in Molecular Biology™ series.
With its multi-disciplinary approach, Clinical Proteomics provides integrated, cutting-edge techniques sure to be invaluable to a wide range of researchers including clinicians, molecular biologists, chemists, bioinformaticians and computational biologists.
Compiled by experts in the field, these protocols demonstrate the widespread use of proteomic techniques used in clinical bench work. Step-by-step instructions that ensure successful results Integrates biochemistry, pathology, analytical technology, bioinformatics, and proteomics.
Autor*in
Antonia Vlahou
Themen in »Clinical Proteomics«
2D electrophoresis Clinical proteomics Computational biology Polyacrylamid-Gelelektrophorese Proteomics biochemistry bioinformatics biomarkers cells molecular biology protein profiling tissue
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From the reviews:
"Clinical proteomics is a fledgling field that is struggling to define its standards and whose underlying technologies continue to evolve at a very rapid pace. ... This multiauthored book provides state-of-the-art information and practical protocols on these topics and many other related areas. ... provides a wealth of background information and underlying principles. ... Overall, this is an excellent book whose natural readership includes both newcomers to the field and seasoned biomarker hunters who wish to update their knowledge or explore new techniques." (Marco Crescenzi, Annali dell'Istituto Superiore di Sanita, Vol. 44 (3), November, 2008)
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