Transgenic and Mutant Tools to Model Brain Disorders
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Beschreibung
As the presence of genetically modified animal models in research laboratories has multiplied, the role of genetic factors in the pathogenesis of brain disorders has become particularly important. The refinement of molecular genetic methods has continued to broaden our understanding of the genetic factors associated with a variety of disorders. In Transgenic and Mutant Tools to Model Brain Disorders, leading scientists specializing in this field contribute a timely collection of recent advances featuring a vast array of topics in order to contribute to the diverse approaches taken toward the evaluation of genetically modified models in biomedical research. Opening with several chapters covering general aspects of genetically modified animal models, the book then continues with detailed chapters on models of specific human brain disorders, including OCD, Rett Syndrome, anxiety disorders, depression, and schizophrenia. As a volume in the successful Neuromethods™ series, the chapters provide authoritative reviews covering the most commonly used approaches in the field.
Cutting-edge and concise, Transgenic and Mutant Tools to Model Brain Disorders offers a comprehensive and descriptive overview on a variety of topics in neuroscience and biological psychiatry.
As the presence of genetically modified animal models in research laboratories has multiplied, the role of genetic factors in the pathogenesis of brain disorders has become particularly important. The refinement of molecular genetic methods has continued to broaden our understanding of the genetic factors associated with a variety of disorders. In "Transgenic and Mutant Tools to Model Brain Disorders", leading scientists specializing in this field contribute a timely collection of recent advances featuring a vast array of topics in order to contribute to the diverse approaches taken toward the evaluation of genetically modified models in biomedical research. Opening with several chapters covering general aspects of genetically modified animal models, the book then continues with detailed chapters on models of specific human brain disorders, including OCD, Rett Syndrome, anxiety disorders, depression, and schizophrenia. As a volume in the successful Neuromethods™ series, the chapters provide authoritative reviews covering the most commonly used approaches in the field.
Cutting-edge and concise, "Transgenic and Mutant Tools to Model Brain Disorders" offers a comprehensive and descriptive overview on a variety of topics in neuroscience and biological psychiatry.
Provides an easily accessible reference volume for animal models in behavioral neuroscience research Details the process of turning a biological observation into a high-throughput screen Covers a wide range of species from zebrafish to rats Addresses a wide spectrum of brain disorders, from anxiety to schizophrenia Presents a modular approach to experimental modelling of brain disorders Comprehensive guide to translational biopsychiatry research focusing on genetic factors in brain disorders
Autor*in
Allan V. Kalueff
Themen in »Transgenic and Mutant Tools to Model Brain Disorders«
Biological psychiatry Genetic diseases Genetically modified animal models Human brain Knockout mice Pathogenesis behavior psychiatry
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From the reviews:
“This is an exceptionally interesting new book on the use of animal models, specifically transgenic and mutant models, in the understanding of brain disorders. … Written and edited by internationally recognized experts in the field, this is a welcome introduction to this subject. … They target scientists ‘from all backgrounds and levels of experience.’ … an excellent book on an important area of study in gene-brain-behavior relationships. Researchers in this field would benefit from reading this interesting book.” (Michael Joel Schrift, Doody’s Review Service, August, 2010)()