Cardiovascular Genomics
Methods and Protocols
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Beschreibung
As two of the leading causes of death worldwide, heart disease and stroke represent a clear target for genomic research aimed at deciphering the genes and cellular pathways that underlie cardiovascular disease and creating improved therapies. In Cardiovascular Genomics: Methods and Protocols, experts in the field provide methods for cardiovascular phenotyping of rodent models in the first section of the volume and for statistical and bioinformatic integration of phenotype data with genome-wide genotype and expression data in the second section. Understanding these diverse methods will allow an individual laboratory to utilize these genomic methods independently or to better prepare for collaboration with scientists having expertise in other disciplines in order to uncover genes affecting cardiovascular disease. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary equipment, materials, and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.
Cutting-edge and easy-to-use, Cardiovascular Genomics: Methods and Protocols will enable researchers to identify causal genes and novel molecular targets that can lead to vital new treatments for cardiovascular disease.
As two of the leading causes of death worldwide, heart disease and stroke represent a clear target for genomic research aimed at deciphering the genes and cellular pathways that underlie cardiovascular disease and creating improved therapies. In Cardiovascular Genomics: Methods and Protocols, experts in the field provide methods for cardiovascular phenotyping of rodent models in the first section of the volume and for statistical and bioinformatic integration of phenotype data with genome-wide genotype and expression data in the second section. Understanding these diverse methods will allow an individual laboratory to utilize these genomic methods independently or to better prepare for collaboration with scientists having expertise in other disciplines in order to uncover genes affecting cardiovascular disease. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary equipment, materials, and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.
Cutting-edge and easy-to-use, Cardiovascular Genomics: Methods and Protocols will enable researchers to identify causal genes and novel molecular targets that can lead to vital new treatments for cardiovascular disease.
Covers a range of phenotyping, bioinformatics, and statistical methods required for cardiovascular genomic research Detailed protocols for evaluating important cardiovascular diseases in rodents Highlights expert insights to avoid or overcome technical difficulties phenotyping rodent models Includes methods for integrating genotype, gene expression, and phenotype data from rodents and humans Provides bioinformatics and statistical methods applicable to genomic research into many varied diseases Includes supplementary material: sn.pub/extras
Autor*in
Keith DiPetrillo
Themen in »Cardiovascular Genomics«
Atherosclerosis Bioinformatics and statistics Genotyping Heart disease Hypertension Microarray Phenotyping Rodent models Stroke bioinformatics cardiovascular genes molecular biology gene expression
Stimmen zu »Cardiovascular Genomics«
From the reviews:
“The book appears to provide a practical guide on a number of laboratory-based molecular methods that are likely to be useful in carrying out human and animal experiments to generate data and information for … complex cardiovascular conditions. … Although this book is well produced with excellent layout, it will probably find a … place on any researcher’s book shelf. … laboratories may consider keeping a copy in the library for quick reference and useful in teaching and training of young investigators in molecular genomics.” (Dhavendra Kumar, Human Genetics, Vol. 127, 2010)
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