Transforming Growth Factor-Beta in Cancer Therapy, Volume II
Cancer Treatment and Therapy
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Beschreibung
Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provides a compendium of findings about the role of transforming growth factor-ß (TGF-ß) in cancer treatment and therapy. The second volume, Cancer Treatment and Therapy, is divided into three parts. Part I examines transforming growth factor-ß in developing and advanced cancers. Part II details transforming growth factor-ß in cancer treatment and therapy. Part III includes an investigation into the development of inhibitors of transforming growth factor-ß signaling for therapy.
This volume’s companion, Basic and Clinical Biology, examines transforming growth factor-ß signaling in normal physiology, cancer pathobiology, normal and tumor biology, and inflammation and fibrosis. Together, Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor-ß in biology and cancer treatment.
Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF-~ has been linked to several diseases. For instance, the effect ofTGF-~ on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF-~ has a very complicated role in cancer that is only beginning to be understood.
Details the role of TGF- ß in cancer treatment and therapy, including its role in development and progression of several different cancers Conveniently divided into three easy-to-follow parts Companion volume details the role of TGF- ß on basic and clinical biology
Autor*in
Sonia B. Jakowlew
Themen in »Transforming Growth Factor-Beta in Cancer Therapy, Volume II«
Activation DNA Endoplasmatisches Reticulum Vivo angiogenesis carcinoma gene transfer genes leukocytes positron emission tomography regulation tissue translation tumor growth tumorigenesis
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From the reviews:
"This volume … provide readers with a detailed account of the role of TGF-beta in the development of various cancers in numerous organs. … This will likely be of interest to those in the field as well as those who are new … . will be of interest to researchers at all levels. The book will likely attract new researchers and students interested in becoming engaged in new frontiers of cancer therapy. … This will be a great resource for researchers and clinicians … ." (James P Luyendyk, Doody’s Review Service, June, 2008)
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