Essential Concepts in Toxicogenomics
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Beschreibung
The field of toxicogenomics has been growing quickly, yet with rapid growth comes the need to periodically reflect on the nature of the field. Essential Concepts in Toxicogenomics collects reviews, opinion pieces and case studies from the leading experts in this dynamic field with a focus on its application to pharmaceuticals. Topics covered include issues that affect the quality of toxicogenomics experiments, statistical approaches to their data analysis, the use of such data to build toxicogenomic models, and the utilization of genomics to identify biomarkers within the preclinical and clinical arenas. Although not in the standard Methods in Molecular Biology™ series format, this volume retains the practicality and usefulness of the highly successful series.
Informative and cutting-edge, Essential Concepts in Toxicogenomics is an ideal resource for pharmaceutical companies, chemical manufacturers, toxicologists, and all who must keep up-to-date on progress in this vital and important field.
Includes contributions from experts in fields as diverse as the pharmaceutical industry, biotechnology companies, regulatory agencies, non-profit organizations and academia Covers the many uses of toxicogenomics spanning its predictive application, use in mechanistic analysis, and consideration for risk assessment Discusses the issues that currently limit its universal acceptance including cross species correlations, regulatory uncertainty and biomarker validation
Autor*in
Donna L. Mendrick
Themen in »Essential Concepts in Toxicogenomics«
Annotation Biomarkers Genomic data Microarray Regulatory implications Toxicity Toxicogenomic models Translation bioinformatics genes genome molecular biology
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From the reviews:
"‘Essential Concepts in Toxicogenomics’ is a collections of reviews, opinion pieces and case studies written by experts in the field. … gives good coverage of whole field of toxicogenomics. … If you want to get up to steam with this area then … it is certainly worth reading this book." (James Sidaway, BTS Newsletter, Winter, 2008)
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