Natural Products Isolation

Beschreibung

Building on the high reputation of the first edition of Natural Products Isolation, the authors have in this second edition not only significantly updated all the techniques to reflect recent advances in the field, but also added three new chapters on hyphenated techniques, purification by solvent extraction using partition coefficient, and isolation of microbial natural products. These readily reproducible methods make it possible for even the novice to extract, prepare, and isolate natural products from given source materials. The book includes not only powerful cutting-edge techniques, but also simple basic techniques that can save time and effort, as well as achieve results equivalent to using some of the more modern and expensive methodologies. The protocols follow the successful Methods in Biotechnology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Up-to-date and highly practical, Natural Products Isolation, Second Edition, offers the aspiring natural products researcher all the information needed to attain mastery of essential methods and the more experienced investigator a useful reference guide to all the available techniques.
The term “natural products” spans an extremely large and diverse range of chemical compounds derived and isolated from biological sources. Our interest in natural products can be traced back thousands of years for their usefulness to humankind, and this continues to the present day. Compounds and extracts derived from the biosphere have found uses in medicine, agriculture, cosmetics, and food in ancient and modern societies around the world. Therefore, the ability to access natural products, understand their usefulness, and derive applications has been a major driving force in the field of natural product research. The first edition of Natural Products Isolation provided readers for the first time with some practical guidance in the process of extraction and isolation of natural products and was the result of Richard Cannell’s unique vision and tireless efforts. Unfortunately, Richard Cannell died in 1999 soon after completing the first edition. We are indebted to him and hope this new edition pays adequate tribute to his excellent work. The first edition laid down the “ground rules” and established the techniques available at the time. Since its publication in 1998, there have been significant developments in some areas in natural product isolation. To capture these developments, publication of a second edition is long overdue, and we believe it brings the work up to date while still covering many basic techniques known to save time and effort, and capable of results equivalent to those from more recent and expensive techniques.

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Satya D. Sarker

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". . . offers extensive help in the selection of a suitable methodology. . .an excellent aid. . .closes a painfully evident gap in the selection of monographs on natural products chemistry. . .warmly recommended to anyone interested in the isolation of natural products."-Angewandte Chemie

". . .a very good general reference that concentrates a considerable amount of useful practical information. . .well worth considering as a reference for graduate students or other researchers who might need to familiarize themselves with the intricacies of the subject."-Journal of Natural Products

"...contains a wealth of practical information, hints, and useful points...an asset in any laboratory where natural products isolation is performed." -Journal of Medicinal Chemistry

"...a very good general reference that concentrates a considerable amount of useful practical information." -Pathology

"...excellent and comprehensive...wholeheartedly recommend[ed]...as a comprehensive handbook for solving problems in daily research." -Drug Discovery Today
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