Electrophysiological Analysis of Synaptic Transmission
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Beschreibung
Electrophysiology is one of the finest approaches capable of detecting and analyzing electrical events in the brain. However, like all other experimental approaches, it has its limitations. This book was created to serve as a guide for those endeavoring to understand the function of electrophysiology and its underlying components: neurons, neural systems, and the brain. It introduces and highlights important topics in the field of electrophysiology, while also extending these topics to practical electrophysiological approaches through the perspective of the two authors. This book is ideal for graduate students or junior postdoctoral fellows interested in starting a journey in synaptic neuroscience.
Electrophysiological methods are used at nearly all levels of biological research today. From basic science investigation to bringing new drugs to market, electrophysiology is an indispensable research technique that provides essential insights into cellular and molecular functions. This work is intended to be a practical guide for understanding and using contemporary electrophysiological manipulations and assays in brain research. New researchers attempting to learn electrophysiological techniques are confronted with a lack of adequate guiding resources. Currently, most electrophysiology-based research knowledge is passed on by experienced individuals to others within the same laboratory. But, this master-apprentice scenario has many inherent difficulties, as it is both a time intensive process and also leads to incomplete knowledge transfer, or even superstitious and maladaptive practices. Few external guiding resources exist for a budding researcher who wishes to gain the skills necessary to conduct responsible and competent electrophysiology research. Dr. Yan Dong, an expert in utilizing electrophysiological techniques for brain research with fifteen years of experience, and Peter Neumann hope this work can act as a concise and practical aid to remedy the current situation. This book will cover both basic methods and advanced techniques clearly and in depth, as well as the essential background and theory necessary to understand the methods. Additionally, this book also covers conventional and contemporary patch-clamp methods, experimental design, data collection and analysis, common pitfalls to avoid, important nuances, technical concerns, practical applications, and advice for teaching new researchers. Together, this represents a contemporary best-practices guide for collecting and interpreting electrophysiological data for brain research.
A practical guide to electrophysiological manipulations and assays in brain research A best-practices guide for collecting and interpreting data Intended for senior undergraduates and above? Includes supplementary material: sn.pub/extras
Autor*in
Nicholas Graziane
Themen in »Electrophysiological Analysis of Synaptic Transmission«
analysis brain electrophysiology methods patch-clamp synapse
Stimmen zu »Electrophysiological Analysis of Synaptic Transmission«
“This book can be consulted as a ‘how to’ manual for investigator. It is an excellent book for physiologists, biomathematicians, students, postdocs, engineers, and biochemists with an interest in neurophysiology. Established researchers may find it useful also.” (Joseph J. Grenier, Amazon.com, February, 2016)
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