Chemical Library Design
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Beschreibung
Chemical library technologies have brought about dramatic changes in the drug discovery process, and, though still evolving, they have become an integral part of ongoing drug discovery research. In Chemical Library Design, experts in the field provide methods and detailed protocols delving into this key process of selecting useful, biologically relevant compounds from large pools of synthesizable candidates. This compendium includes chapters on historical overviews, state-of-the-art methodologies, including structure-based and fragment-based library design, practical software tools, and successful and important applications of chemical library design. As a volume in the popular Methods in Molecular Biology™ series, the thorough contributions provide the kind of meticulous description and implementation advice that is crucial for getting optimal results.
Authoritative and cutting-edge, Chemical Library Design is an ideal reference for all scientists seeking the technology needed to aid in the search for new and vital drugs.
Chemical library technologies have brought about dramatic changes in the drug discovery process, and, though still evolving, they have become an integral part of ongoing drug discovery research. In Chemical Library Design, experts in the field provide methods and detailed protocols delving into this key process of selecting useful, biologically relevant compounds from large pools of synthesizable candidates. This compendium includes chapters on historical overviews, state-of-the-art methodologies, including structure-based and fragment-based library design, practical software tools, and successful and important applications of chemical library design. As a volume in the popular Methods in Molecular Biology™ series, the thorough contributions provide the kind of meticulous description and implementation advice that is crucial for getting optimal results.
Authoritative and cutting-edge, Chemical Library Design is an ideal reference for all scientists seeking the technology needed to aid in the search for new and vital drugs.
Presents protocols with a design-based focus, from introductory overviews to detailed applications Provides contributions from expert practitioners featuring their tips for successful implementation of the techniques Includes sections on structure-based design, fragment-based design, design for kinase families, and key tools for design
Autor*in
Joe Zhongxiang Zhou
Themen in »Chemical Library Design«
Chemoinformatics Combinatorial libraries Drug discovery process Fragment-based library design High throughput screening Pharmaceutical design Software tools Structure-based library design
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From the reviews:
“This book contains 18 chapters divided into five sections. … great interest to investigators designing and synthesizing chemical libraries. … would be exceedingly useful to programmers or designers interested in developing combinatorial chemical library software utilities and, as such, will appeal to that audience. … very useful to a broad audience interested in chemical library design … . it is easy to read. … a valuable resource that should be educational and serve as a good resource for those interested in Chemical Library Design.” (David L. Roman, Journal of Medicinal Chemistry, Vol. 54 (12), 2011)()