Animal Models of Dementia
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Beschreibung
With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer’s disease, Parkinson’s disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models.
Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.
With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer’s disease, Parkinson’s disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models.
Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.
Appeals to a broad readership from neuropathologists, pharmacists, biochemists, and biologists to clinical neurologists Features a large, comprehensive section on Alzheimer’s disease Includes contributions from prominent investigators sharing their experience through detailed, easily accessible methods Includes supplementary material: sn.pub/extras
Autor*in
Peter Paul De Deyn
Themen in »Animal Models of Dementia«
Alzheimer’s disease Brain diseases Cognitive impairment Drug discovery and development Neurodegeneration Neurological disorders New therapeutic targets Preclinical research Vascular dementia
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From the book reviews:
“A complete guide to lesion induced, genetic knockout, and phylogenetic approaches to dementias is catalogued. … I recommend this book for animal researcher for sure, and neurologists in particular.” (Joseph J. Grenier, Amazon.com, August, 2014)
“A great add-on to more basic textbooks on mechanisms of dementia. The book not only nicely summarizes ongoing efforts to model dementia but also describes how to investigate underlying mechanisms at various level of complexity. … Importantly, leading mouse models are discussed, which is very useful for newcomers to the field, as there are a lot of different models. … Additionally, the book provides information about ethics on animal experimentation and information on intellectual property, issues that can be rarely found in textbooks.” (Karl Peter Giese, British Journal of Clinical Pharmacology, May, 2011)()