Tumor Metabolome Targeting and Drug Development
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Beschreibung
In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.
The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate. However, the metabolism of malignant cells generally varies from that of normal cells. These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.
In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.
The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate. However, the metabolism of malignant cells generally varies from that of normal cells. These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.
Provides expert reviews of multiple metabolic targets covering the glycolytic pathway, Krebs cycle, tumor microenvironment, hypoxia, and therapeutic strategies Explores experimental models for evaluating the tumor metabolome to provide knowledge and access to the field Bridges the fields of cancer cell metabolism, tumor/stroma microenvironments, autophagy, drug discovery and development, and translational application of novel cancer therapies Includes supplementary material: sn.pub/extras
Autor*in
Steven Kanner
Themen in »Tumor Metabolome Targeting and Drug Development«
drug development targeting tumor tumor metabalome Metabolomics