Hormone Signaling
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Beschreibung
Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis.
The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.
Autor*in
Vincent Goffin
Themen in »Hormone Signaling«
EGF receptor G protein-coupled receptors TSH receptors cytokine receptors erythropoietin estrogen action estrogen receptor growth hormone receptors insulin leptin receptors metabolic control protein phosphorylation signaling system spatio-temporal parameters thrombopoietin