Tandem Repeat Polymorphisms

Beschreibung

This book addresses the role of tandem repeat polymorphisms (TRPs) in genetic plasticity, evolution, development, biological processes, neural diversity, brain function, dysfunction and disease. There are hundreds of thousands of unique tandem repeats in the human genome and their polymorphic distributions have the potential to greatly influence functional diversity and disease susceptibility. Recent discoveries in this expanding field are critically reviewed and discussed in a range of subsequent chapters, with a focus on the role of TRPs and their various gene products in evolution, development, diverse molecular and cellular processes, brain function and disease.
Focuses on key aspects of TRPs in health and disease Provides a detailed discussion of repeat sequences as mutable sites providing genetic variability upon which natural selection can act Provides insights into how expanded polyalanine in specific proteins leads to developmental abnormalities and neurocognitive dysfunction

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Anthony J. Hannan

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Anthony J. Hannan Polymorphism Repeat Polymorphisms TRPs Tandem

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