Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines
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Beschreibung
Vaccine discovery is one of the most exciting and fast-moving areas of applied science. Since Edward Jenner’s work in the 18th century, vaccines have transformed health across the globe. Bringing together clinical, experimental, and computational disciplines vaccinology addresses the most pressing needs of 21st century health-care: the great infectious diseases threatening the developing world, such as HIV, Malaria, and TB; and chronic diseases, such as dementia, threatening the developed world.
This volume seeks to expand the horizons of vaccine design and discovery by highlighting cutting edge work in three areas of vaccinology: the rational discovery of subunit vaccines, the identification of adjuvants, and the delivery of vaccines via state-of-the-art nanotechnology.This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.
Will address an important emergent area within immunomics: adjuvants Explores ways to make vaccines more effective There is no such book like this one Includes supplementary material: sn.pub/extras
Autor*in
Darren R. Flower
Themen in »Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines«
Adjuvants Antigens Immunomics Reverse Vaccinology vaccines
Stimmen zu »Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines«
Details
ISBN: 9781461450702
Verlag: Springer US
Erscheinung: 09.12.2012