Human Protein Metabolism is a succinct review of hundreds of studies on the regulation of protein mass and protein turnover in the human body. The biochemistry of protein synthesis and breakdown is summarized, and the methods that are used to examine protein metabolism in humans are explained, and their limitations discussed. The book includes chapters that review the effects of nutrition, hormones, metabolic substrates, and physical activity. Various topics of clinical interest are covered, including cancer, diabetes, tissue injury, pregnancy, renal disease, muscular dystrophies, and other conditions. Normal values are presented for turnover of proteins in the whole body and individual organs, and for turnover of many individual proteins. This book will be a valuable resource for physiologists, nutritionists, and clinicians interested in the regulation of body protein stores in health and disease. For scientists primarily interested in the basic aspects of protein metabolism, it shows how the basic knowledge is being applied to the study of humans.
This book provides a thorough source of information on the methods used to study protein metabolism in humans, and what we have learned by using these methods. The book focuses on understanding the principles of the methods, and on their limitations. It discusses the basic concepts and mechanisms of protein dynamics and turnover, nutritional influences and the regulation of the process by hormones and by general metabolic regulation. A chapter covers the role of physical activity in modulating protein metabolism. Clinical aspects, such as diabetes, obesity, anorexia and malnutrition are also included.
Stephen Welle
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