Statistics Applied to Clinical Trials
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Beschreibung
In 1948 the first randomized controlled trial was published by the English Medical Research Council in the British Medical Journal. Until then, observations had been uncontrolled. The intervening decades have seen significant improvement in the accuracy of trials. Today, clinical trial protocols are now routinely scrutinized by ethics committees, institutional and federal review boards, national and international scientific organizations, and monitoring committees charged with conducting interim analyses. The updated Third Edition of Statistics Applied to Clinical Trials explains classical statistical analyses of clinical trials, but equivalence testing, interim analyses, sequential analyses, meta-analyses, and provides a framework of the best statistical methods currently available for such purposes.
The authors have both medical and mathematical backgrounds Based on famous modules from the Socrates educational project Eudipharm of the EC Innovative because of the explanatory rather than mathematical approach Emphasizes non-classical but increasingly frequently used methods such as equivalence testing, interaction assessment and analysis of genetic data Not equivalent to any current textbook on statistics
Autor*in
Ton J. Cleophas
Themen in »Statistics Applied to Clinical Trials«
Analysis of variance Measure Regression analysis data analysis linear regression statistics
Stimmen zu »Statistics Applied to Clinical Trials«
From the reviews of the fourth edition:
"Readership: Students, physicians and investigators interested in statistical methods for clinical trials. This book was originally written for a course in medical statistics given in the EU sponsored program European Interuniversity Diploma of Pharmaceutical Medicine starting in the year 2000. … it has been expanded and updated in order to serve as a guide and reference-text to students, physicians and investigators." (Andreas Rosenblad, International Statistical Review, Vol. 77 (3), 2009)
“The book is written for students in health care and physicians and can be viewed as a guide and reference textbook. … an important contribution to the clinical trials and medical statistics community. … The book’s main strength is its presentation, which deepens the knowledge and understanding of applications of statistical methods and analyses of clinical trials. … The many good motivating examples make the book a useful resource for instructors teaching introductory statistics courses. I enjoyed reading this book, and you will too.” (Technometrics, Vol. 52 (2), May, 2010)
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