RAS Family GTPases
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Beschreibung
Since 1982, Ras proteins have been the subject of intense research investigation by the
biomedical research community. The wide interest in Ras has been stimulated for
three key reasons.
First, their frequent mutational activation in human cancers establishes Ras proteins
as important mediators of oncogenesis and targets for anti-cancer drug discovery.
Second, Ras proteins act as signalling nodes activated by diverse extracellular
stimuli, and activated Ras in turn regulates a diversity of cytoplasmic signalling
networks.
Third, Ras proteins are founding members of a large superfamily of Ras-related small
GTPases. Over 150 Ras-related small GTPases are found in the human genome, with
orthologs found in all vertebrate species and invertebrates.
This book features chapters by leading investigators in the field that highlight the
current state-of-the art in Ras biochemistry, structure and biology.
This book is an excellent reference for students in the biomedical sciences and for
investigators in the field.
Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons.
First, their frequent mutational activation in human cancers establishes Ras proteins as important mediators of oncogenesis and targets for anti-cancer drug discovery. Second, Ras proteins act as signalling nodes activated by diverse extracellular stimuli, and activated Ras in turn regulates a diversity of cytoplasmic signalling networks. Third, Ras proteins are founding members of a large superfamily of Ras-related small GTPases. Over 150 Ras-related small GTPases are found in the human genome, with orthologs found in all vertebrate species and invertebrates.
This book features chapters by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.
Focuses on one of the most intensely studied proteins and areas in cell biology Establishes many of our current paradigms in the signalling circuitry of a cell Of interest to researchers in a diverse spectrum of areas, from invertebrate development to cancer treatment A major area of focus of the pharmaceutical industry for the development of target-based anti-cancer drugs
Autor*in
Channing Der
Themen in »RAS Family GTPases«
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