Protein NMR Spectroscopy
Practical Techniques and Applications
Buch in deiner Nähe kaufen
Beschreibung
Nuclear Magnetic Resonance (NMR) spectroscopy, a physicalphenomenon based upon the magnetic properties of certain atomicnuclei, has found a wide range of applications in life sciencesover recent decades. The dramatic advances in NMR techniques haveled to corresponding advances in the ability of NMR to studystructure, dynamics and interactions of biological macromoleculesin solution under close to physiological conditions. This volumefocuses on the use of NMR to study proteins.
NMR can be used to determine detailed three-dimensionalstructures of proteins in solution. Furthermore, it providesinformation about conformational or chemical exchange, internalmobility and dynamics at timescales varying from pcoseconds toseconds. It is the primary technique used to obtain information onintrinsically disordered (unfolded) proteins, since these proteinswill not crystallize easily. NMR is also a very powerful method forthe study of interactions of protein with other molecules, whethersmall molecules (including drugs), nuclear acids or otherproteins.
This up-to-date volume covers NMR techiniques and theirapplication to proteins, with a focus on practical details. Thisbook will provide a newcomer to NMR with the practical guidance inorder to carry out successful experiments with proteins and toanalyze the resulting spectra. Those who are familiar with thechemical applications of NMR will also find is useful inunderstanding the special requirements of protien NMR.
Autor*in
Gordon Roberts
Themen in »Protein NMR Spectroscopy«
Biochemie u. Chemische Biologie Biochemistry (Chemical Biology) Biowissenschaften Cell & Molecular Biology Chemie Chemistry Life Sciences NMR Spectroscopy / MRI / Imaging NMR-Spektroskopie NMR-Spektroskopie / MRT / Bildgebende Verfahren Proteine Zell- u. Molekularbiologie
Stimmen zu »Protein NMR Spectroscopy«
"This is a must for anyoneinterested in using solution NMR to study proteins. SummingUp: Highly recommended. Graduate students,researchers/faculty, and professionals/practitioners." (Choice, 1 April 2012)
()