Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience
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Beschreibung
The book consists of a brief introduction, a foreward provided byprofessor Danishefsky of Columbia University, and about 14 -16 chapters, each written by one or two eminent scholars/authorsdescribing their recent research in the area of either dominoreactions or intramolecular rearrangements in carbohydratechemistry. Three or
four chapters will be reviews. The domino (cascade, tandem)reactions are always intramolecular. They are usually very fast,clean and offer highly complex structures in a one pot process.Intramolecular rearrangements offer very similar advantages andoften lead to highly complex products as well. Although manyrecently isolated carbohydrates fulfill various sophisticatedfunctions, their structures are often very complex. The editorscover the broadest scope of novel methodologies possible. All thesynthetic and application aspects of domino/cascade reactions areexplored in this book. A second theme that will be covered isintramolecular rearrangement, which is also fast, stereoselective,and often constitutes one or more steps of domino /cascade process.Selected examples of intramolecular rearrangements are presented.Together, both processes offer an elegant and
convenient approach to the synthesis of many complex molecules,which are normally difficult to synthesize via alternative routes.It appears that domino and intramolecular rearrangements areideally suited to synthesize certain specific modifiedmonosaccharides. What is particularly important is that bothprocesses are intermolecular and almost always yield products withvery well-defined stereochemistry. This high definition isabsolutely crucial when synthesizing advanced, modified mono andoligosaccharides. The choice of contributors reflects anemphasis
on both therapeutic and pharmacological aspects of carbohydratechemistry.
Autor*in
Zbigniew J. Witczak
Themen in »Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience«
Biochemie Biochemie u. Chemische Biologie Biochemistry (Chemical Biology) Chemie Chemistry Drug Discovery & Development Organic Chemistry Organische Chemie Wirkstoffforschung Wirkstoffforschung u. -entwicklung