Oral Bioavailability Assessment
Basics and Strategies for Drug Discovery and Development
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Beschreibung
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability - one of the most significant hurdles in drug discovery and development.
* Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
* Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
* Explains how preclinical animal models - used in preclinical testing - and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
* Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
* Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
Autor*in
Ayman F. El-Kattan
Themen in »Oral Bioavailability Assessment«
Analytical Chemistry Analytische Chemie Chemie Chemistry Clinical Pharmacology & Therapeutics Drug Discovery & Development Klinische Pharmakologie u. Therapie Medical Science Medizin Pharmakologie Wirkstoffforschung Wirkstoffforschung u. -entwicklung