ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins

Beschreibung

With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. * Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs * Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective * Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines * Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan * Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain

Autor*in

Honghui Zhou

Themen in »ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins«

Biopharmaceuticals & Pharmaceutical Biotechnology Biopharmazeutika u. Pharmazeutische Biotechnologie Biowissenschaften Cell & Molecular Biology Chemie Chemistry Clinical Pharmacology & Therapeutics Klinische Pharmakologie u. Therapie Life Sciences Medical Science Medizin Pharmakokinetik Pharmakologie Zell- u. Molekularbiologie

Stimmen zu »ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins«

"At the outset, one?s impressed with the scope of the book; it provides an outline of very diverse topics starting with the basics of protein engineering and how these are used to design and manipulate the ADME properties of recombinant and synthetic proteins...The authors have to be congratulated on their endeavor to stitch these topics together in a single book...With such a wide range of topics, even an experienced scientific practitioner in this area is likely to find something new to engage them and expand their knowledge...In summary, an excellent and comprehensive book for beginners to the CP/PK area to acquaint themselves with the area of biologics (specifically mAb) CP/PKPD principles and for experienced CP/PK scientists for reference." (CPT: Pharmacometrics & Systems Pharmacology, March 2017)
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