Chemical Synthesis of Nucleoside Analogues

Beschreibung

Compiles current tested and proven approaches tosynthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists fromaround the world, this book brings together and describes testedand proven approaches for the chemical synthesis of common familiesof nucleoside analogues. Readers will learn to create newnucleoside analogues with desired therapeutic properties by using avariety of methods to chemically modify natural nucleosides,including: * Changes to the heterocyclic base * Modification of substituents at the sugar ring * Replacement of the furanose ring by a different carbo- orheterocyclic ring * Introduction of conformational restrictions * Synthesis of enantiomers * Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all themajor classes of nucleosides, including pronucleotides,C-nucleosides, carbanucleosides, and PNA monomers which have showngreat promise as starting points for the synthesis of nucleosideanalogues. The book also includes experimental procedures for keyreactions related to the synthesis of nucleoside analogues,providing a valuable tool for the preparation of a number ofdifferent compounds. Throughout the book, chemical schemes and figures help readersbetter understand the chemical structures of nucleoside analoguesand the methods used to synthesize them. Extensive references serveas a gateway to the growing body of original research studies andreviews in the field. Synthetically modified nucleosides have proven their value astherapeutic drugs, in particular as antiviral and antitumor agents.However, many of these nucleoside analogues have undesirable sideeffects. With Chemical Synthesis of Nucleoside Analogues astheir guide, researchers have a new tool for synthesizing a newgeneration of nucleoside analogues that can be used as therapeuticdrugs with fewer unwanted side effects.

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Pedro Merino

Themen in »Chemical Synthesis of Nucleoside Analogues«

Biochemie u. Chemische Biologie Biochemistry (Chemical Biology) Bioorganic Chemistry Bioorganische Chemie Chemie Chemische Synthese Chemistry Methods - Synthesis & Techniques Nukleoside Organische Chemie / Methoden, Synthesen, Verfahren

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