Kinase Inhibitor Drugs
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Beschreibung
A comprehensive resource on case studies of marketed kinasedrugs and promising drug trials
Since the discovery of protein kinase activity in 1954, thefield of protein kinase drug discovery has advanced dramatically.With the ongoing clinical success of the Bcr-Abl kinase inhibitorGleevec in the treatment of chronic myelogenous leukemia and sevenadditional marketed kinase inhibitor drugs, researchers havecompelling evidence that kinase inhibitors can be highlyefficacious in the treatment of diseases caused by aberrantactivity of protein kinase. Currently more than 100 protein kinaseinhibitors are in clinical development.
In one comprehensive volume, the editors, Dr. Rongshi Li and Dr.Jeffrey Stafford, present timely and important case studies ofmarketed kinase drugs and several of the most advanced kinaseinhibitors in clinical trials. Kinase Inhibitor Drugsincludes:
* Case studies from leading investigators and experts in the fieldthat provide firsthand accounts of kinase inhibitor discovery
* Current thinking on kinase structure, biochemistry, and signaltransduction pathways
* Information on state-of-the-art technologies and tools such asstructure-based and fragment-based drug discovery
* A lineup of clinical-phase growth factor receptor inhibitors
* Inhibitors of cell cycle kinases
* The discovery of allosteric inhibitors of MEK kinase
* Information on pharmacogenomics and its application to kinaseinhibitor clinical development
Autor*in
Rongshi Li
Themen in »Kinase Inhibitor Drugs«
Biowissenschaften Cell & Molecular Biology Chemie Chemistry Drug Discovery & Development Life Sciences Medical Science Medizin Molekularbiologie Pharmacology & Pharmaceutical Medicine Pharmakologie Pharmakologie u. Pharmazeutische Medizin Wirkstoffforschung Wirkstoffforschung u. -entwicklung Zell- u. Molekularbiologie
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"In conclusion, I strongly recommend this book to anyone who isinterested and new to the field of kinase inhibitors. Indeed, Ibelieve this book should not merely sit on the shelves of kinaseexperts, but should be used frequently for reference."(ChemMedChem, 2010)
"Delivers what the title promises: a comprehensive treatment ofdrugs that inhibit kinases. ... Will be interesting to any chemistor biologist desiring a behind-the-scenes look at modern strategiesof drug discovery and their practical applications to somechallenging targets." (Journal of Medicinal Chemistry, April2010)
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