Detection and Quantification of Antibodies to Biopharmaceuticals
Practical and Applied Considerations
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Beschreibung
The definitive book on the neutralization of recombinantbiopharmaceuticals
Recombinant biopharmaceuticals are an important tool fortreating a range of illnesses; however, their efficacy can beseverely impaired by their immunogenicity. When introduced into thebody, these pharmaceuticals can cause the immune system to produceanti-drug antibodies (ADAs) that neutralize their effects.
The first and only book to cover neutralization in connectionwith biopharmaceuticals and the measurement and application ofneutralizing antibodies in modern medicine at any real length,Detection and Quantification of Antibodies to Biopharmaceuticals:Practical and Applied Considerations offers a comprehensive andin-depth look at all the principal aspects of the detection andquantification of antibodies that are essential to understandingand responding to the challenges they present.
Bringing together a large-scale review of neutralization andbiopharmaceuticals and the ability to measure, detect, and applyantibodies to modern science and medicine with internationalregulatory perspectives, the expectations of regulatoryauthorities, and the strengths and weaknesses of various assays,the book describes several novel ideas for detecting ADAs.
Designed to serve as a resource for biopharmaceutical drugdevelopment, the book provides biotechnology companies andpharmaceutical drug development specialists, as well asnon-experts, with key insights into the design, optimization, andqualification of assays, the establishment of sampling strategies,the choice of appropriate assay end-points, and data analysis forthe detection and quantification of neutralizing antibodies.
Autor*in
Michael G. Tovey
Themen in »Detection and Quantification of Antibodies to Biopharmaceuticals«
Analytical Chemistry Analytische Chemie Chemie Chemistry Drug Discovery & Development Immunologie Immunology Medical Science Medizin Wirkstoffforschung Wirkstoffforschung u. -entwicklung