Role of the Choroid Plexus in Health and Disease
Buch in deiner Nähe kaufen
Beschreibung
This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue.
Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in the choroidplexus is not only important for the readers’ understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia.
Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.
Broadens understanding of the clinical importance of the choroid plexus as the main source of cerebrospinal fluid
gives insights into Drug-development strategies targeting the blood cerebrospinal fluid barrier using the choroid plexus epithelial cells
Emphazises the coorrelation between production and composition of CSF and the maintance of normal brain function
Broadens readers’ understanding of the clinical importance of the choroid plexus as the main source of cerebrospinal fluid Shares insights into drug development strategies targeting the blood / cerebrospinal fluid barrier using choroid plexus epithelial cells Emphasizes the correlation between the production and composition of CSF and the maintenance of normal brain function
Autor*in
Jeppe Praetorius
Themen in »Role of the Choroid Plexus in Health and Disease«
Alzheimers Disease Blood Cerebrospinal Fluid Barrier Brain Development Cerebrospinal Fluid Production Cerebrospinal Fluid (CFS) Production Hydrocephalus Regulated Ion Transport