DNA Damage and Repair

Beschreibung

DNA Damage and Repair offers a critical, cutting-edge review of all major aspects of DNA repair in a wide variety of organisms, including every important model system. Volume I: DNA Repair in Prokaryotes and Lower Eukaryotes focuses on DNA damage and repair in prokaryotic and model eukaryotic systems, emphasizing the significant progress that has been made in the past five years. Written by award-winning researchers at the forefront of their fields, each chapter has undergone a rigorous peer-review cycle to ensure definitive and comprehensive treatment of its topic. Extensive up-to-date references, along with clear figures illustrating complex relationships between DNA repair and other DNA dynamic processes and cell functions, bring this volume to the active frontiers of research. Major topics treated include UV and X-ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in cell cycle regulation. A complementary volume, Volume II: DNA Repair in Higher Eukaryotes, covers mammalian systems and is particularly relevant to human genetic disease and cancer.

This major new treatise provides the reader with up-to-date critical surveys of every important area of research on DNA damage and the mechanisms for its repair in each major system currently under investigation. Authoritative and timely, DNA Damage and Repair is certain to become the new standard reference and resource in the field.
Award-winning researchers review of key aspects of DNA repair in a wide variety of organisms, including all-important model systems. The book focuses on DNA damage and repair in prokaryotic and model eukaryotic systems, emphasizing the significant progress that has been made in the past five years. Each chapter has undergone a rigorous peer-review cycle to ensure definitive and comprehensive treatment. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in cell cycle regulation.

Autor*in

Jac A. Nickoloff

Themen in »DNA Damage and Repair«

Base DNA Escherichia coli Nucleotide Regulation biochemistry enzymes eukaryote genetics prokaryotes recombination saccharomyces cerevisiae transcription

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"It's a remarkable compendium, impressive. . .both in its size and its list of contributing authors. . .as a reference that provides an overview of almost every aspect of the field, DNA Damage and Repair fills a critical niche. It certainly belongs in every well-stocked institutional library and also belongs on the reference shelf of every laboratory where people work on DNA repair. My review copy of Volume 1 was barely out of its wrapper when others in the lab began clamoring for a look at it."-Trends in Biological Sciences

"The present volume of DNA Damage and Repair complements and extends the two previous ones. In my opinion, the most valuable components of this book are comprehensive reviews of DNA repair in systems which have been underexploited with regard to this area of research.... this third volume of DNA Damage and Repair is a highly useful text for certain areas of the field, and should be accessible as a library reference" - Cell
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