Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries

Beschreibung

Solid-phase synthesis of carbohydrates presents unique challengesto synthetic chemists and currently represents one of the hottestareas of research in bioorganic chemistry. Solid SupportOligosaccharide Synthesis and Combinatorial Carbohydrate Librariesaddresses the exciting expectation that solid-phase assembly ofoligosaccharides will have a fundamental impact on the field ofglycobiology. This publication details the methodologies currentlyinvestigated for the attachment of carbohydrates to beads,synthesis including coupling strategies, and removal of the productfrom beads. With chapters written by eminent contributing authors, the materialexplores different synthetic strategies, glycosylation protocols,the use of solid supports versus soluble polymeric supports, and"on-resin" analytical methods. Tremendous progress in the field hasset the stage for Solid Support Oligosaccharide Synthesis andCombinatorial Carbohydrate Libraries to provide a wealth ofinformation on such topics as: * Specific oligosaccharide structures used in signal transductionprocesses * Preparation and screening of glycopeptide libraries * Solid-phase carbohydrate synthesis

Autor*in

Peter H. Seeberger

Themen in »Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries«

Chemie Chemistry Organic Chemistry Organische Chemie

Stimmen zu »Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries«

"a splendid overview over the state of the art of the field"(Perkin Transactions, No.23, 2001) "a valuable addition to the reference literature" (Synthesis, No.5, 2002)
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