Solid-Phase Organic Synthesis
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Beschreibung
Solid-Phase Organic Synthesis Edited by KevinBurgess, Texas A & M University Efficient, high-throughputchemistry is now the focus of many research laboratories.Solid-phase organic syntheses are central to many of thesecombinatorial and parallel screening methodologies. Consequently,they have been a major scientific theme of the 1990s and promise toremain prominent for the first part of the new millennium. Indeed,a bewildering number of papers have entered the literature on thistopic; some report minor modifications enabling transformation ofsolution-phase methods to a solid support, while others reportmajor innovations. Solid-Phase Organic Synthesis collects,highlights, and critiques some of the key developments in thefield.
Leading practitioners explain different perspectives on diverseaspects of the area. Specific topics covered include:
* Syntheses of guanidines
* Palladium-catalyzed C-C bond forming reactions
* S_nAr reactions for the formation of heterocycles
* Sequence-specific arylalkyne oligomers
* Resin-supported capture agents and other reagents
* Synthesis on pins
* Monitoring of supported reactions using IR
* Solid-phase syntheses of natural product derivatives
Of related interest: Combinatorial Chemistry andMolecular Diversity in Drug Discovery, Eric M. Gordon and JamesF. Kerwin 1998 (0-471-15518-7) 544 pp. Combinatorial ChemistrySynthesis and Application, Stephen R. Wilson and Anthony W.Czarnik 1997 (0-471-12687-X) 288 pp.
Autor*in
Kevin Burgess
Themen in »Solid-Phase Organic Synthesis«
Chemie Chemie / Organische Chemie Chemistry Festphasentechnik Methods - Synthesis & Techniques Organische Chemie / Methoden, Synthesen, Verfahren Organische Synthese
Stimmen zu »Solid-Phase Organic Synthesis«
"Collects and critiques key developments in the field...explainsdifferent perspectives on various aspects." (SciTech Book News,March 2001)
"This book seeks to highlight and critique key developments insolid-phase organic synthesis...Overall, the book effectivelyrealizes its goal..." (Journal of the American Chemical Society,Vol. 123, No. 7)
"...an excellent starting point for chemists interested insolid-phase organic synthesis. Certainly, this book should beconsidered as an addition to any medicinal chemists library."(Journal of Medicinal Chemistry Vol. 44, No. 24, 2001)
"...brings together...the latest research in the field,highlighting and reviewing some of the major developments." (ChimieNouvelle)
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