Coverage of structure, bonding, and energetics of the amide bond, including electron density distribution, amide rotation, stereochemistry, spectroscopy, and thermochemistry.
* Specific applications to supramolecular and stereospecific synthesis.
* Key aspects of peptide and protein chemistry are discussed in terms of properties of the amide bond.
* Highlights how the amide linkage participates in the design of enzyme inhibitors, cyclic peptides, and antibacterial agents.
Arthur Greenberg