Regulation of G Protein-Coupled Receptor Function and Expression

Beschreibung

G protein-coupled receptors (GPCRs) constitute the largest single class of receptors and are responsible for mediating much of intracellular mammalian signaling. Indeed, over 40 percent of the pharmacological targets being evaluated by drug companies are related to G protein-coupled receptors. Understanding how GPCRs are regulated is critical in determining waysto control their function and expression. This volume covers basic concepts while providing comprehensive treatment of methods used to examine how the functions of GPCRs are regulated. Chapters in this volume, edited by Dr. Jeffrey Benovic, a world-renowned expert in the study of GPCR regulation, describe: * Current techniques used to define the molecular mechanisms involved in receptor regulation *;Specific techniques employed to characterize receptors * The role of regulatory proteins in modulating receptor function * Methods used to measure receptor trafficking and expression Covering a broad range of fundamental concepts and methodologies which are current in the study of GPCRs, Regulation of G Protein-Coupled Receptor Function and Expression is a vital reference for receptor biochemists, pharmacologists, neuroscientists, molecular biologists, cell biologists, and physiologists. Also in this series: Receptor Localization: Laboratory Methods and Procedures edited by Marjorie A. Ariano Identification and Expression of G Protein-Coupled Receptors edited by Kevin R. Lynch Structure-Function Analysis of G Protein-Coupled Receptors edited by Jürgen Wess
Dieser umfassende Band beschreibt viele der aktuell angewandten Techniken zur Bestimmung der molekularen Mechanismen, die bei der Rezeptorregulation eine Rolle spielen. Behandelt wird ein breites Spektrum wichtiger Grundlagen und Methoden für die Analyse von G Protein-gekoppelten Rezeptoren. Geschrieben von anerkannten Experten auf diesem Gebiet. (01/00)

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Jeffrey L. Benovic

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