Label-Free Technologies For Drug Discovery
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Beschreibung
Over the past two decades the benefits of label-free biosensoranalysis have begun to make an impact in the market, and systemsare beginning to be used as mainstream research tools in many drugdiscovery laboratories.
Label-Free Technologies For Drug Discovery summarises thelatest and emerging developments in label-free detection systems,their underlying technology principles and end-user case studiesthat reveal the power and limitations of label-free in all areas ofdrug discovery.
Label-free technologies discussed include SPR, NMR,high-throughput mass spectrometry, resonant waveguide plate-basedscreening, transmitted-light imaging, isothermal titrationcalorimetry, optical and impedance cell-based assays and otherbiophysical methods. The technologies are discussed in relation totheir use as screening technologies, high-content technologies, hitfinding and hit validation strategies, mode of action and ADME/T,access to difficult target classes, cell-based receptor/ligandinteractions particularly orphan receptors, and antibody and smallmolecule affinity and kinetic analysis.
Label-Free Technologies For Drug Discovery is anessential guide to this emerging class of tools for researchers indrug discovery and development, particularly high-throughputscreening and compound profiling teams, medicinal chemists,structural biologists, assay developers, ADME/T specialists, andothers interested in biomolecular interaction analysis.
Autor*in
Matthew Cooper
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Analytical Chemistry Analytische Chemie Biowissenschaften Cell & Molecular Biology Chemie Chemistry Drug Discovery & Development Life Sciences Wirkstoffforschung u. -entwicklung Zell- u. Molekularbiologie
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"Label-Free Technologies For Drug Discovery summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery." (Laboratory Journal, 10 March 2011)
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