Pharmaceutical Process Chemistry for Synthesis

Beschreibung

There is a need to explain that generic versions of a drug maynot be manufactured by the same process as brand-name drugs andthat the different processes may have dramatically differentenvironmental impacts. Two global forces are at oddstoday--the push for "greener" processes and the push for lowerdrug prices. This book brings this conflict into sharp focus bydiscussing in detail the published process chemistry fortop-selling small molecule drugs. Providing insights about process route selection, choice ofreagents, and reaction conditions, Pharmaceutical ProcessChemistry for Synthesis guides process chemists in identifyingbest processes for manufacturing these blockbuster drugs as theylose patent protection. Further, it highlights the strategies andmethodology that might be useful for expediting the processresearch and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book isessential for process chemists who need to devise practicalsyntheses for increasingly complex drugs in a constantly decreasingtime frame.

Autor*in

Peter J. Harrington

Themen in »Pharmaceutical Process Chemistry for Synthesis«

Chemical Engineering Chemie Chemische Verfahrenstechnik Chemistry Methods - Synthesis & Techniques Organische Chemie / Methoden, Synthesen, Verfahren Pharmaceutical & Medicinal Chemistry Pharmazeutische Chemie Pharmazeutische u. Medizinische Chemie Process Development Verfahrensentwicklung

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"This book presents detailed discussions of the published process chemistry of the ten top-selling small molecule drugs in the US in 2007, information which is usually carefully protected by the current and future manufacturers." (TMCnet.com, 17 March 2011)"[This] book contains a wealth of information, taken from thepatent literature and from [the author's]decades of experience inprocess chemistry. Through discussions on route selection[he]introduces practical aspects of route design, includingselecting non-toxic, stable and inexpensive starting materials,reactions that minimize impurity contents with optimized yields,and ease of purification. [Dr. Harrington] lays out the variousapproaches to successful molecules, including biocatalysis, andsorts out which routes are acceptable, creative, likely to be themanufacturing route, or merely holding space.... [This] book willbe extremely valuable for the process chemist who wants to delvedeeply into details critical for process optimization, and for thestudent new to chemical process R&D in the pharmaceutical andCRO / CMO industries." --Neal G. Anderson, Anderson's Process Solutions LLCand author of Practical Process Research & Development
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