Model Organisms in Drug Discovery
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Beschreibung
Fruit flies are "little people with wings" goes the saying in thescientific community, ever since the completion of the Human GenomeProject and its revelations about the similarity amongst thegenomes of different organisms. It is humbling that most signallingpathways which "define" humans are conserved in Drosophila, thecommon fruit fly.
Feed a fruit fly caffeine and it has trouble falling asleep;feed it antihistamines and it cannot stay awake. A C. elegans wormplaced on the antidepressant flouxetine has increased serotoninlevels in its tiny brain. Yeast treated with chemotherapeutics stoptheir cell division. Removal of a single gene from a mouse orzebrafish can cause the animals to develop Alzheimer'sdisease or heart disease. These organisms are utilized assurrogates to investigate the function and design of complex humanbiological systems.
Advances in bioinformatics, proteomics, automation technologiesand their application to model organism systems now occur on anindustrial scale. The integration of model systems into the drugdiscovery process, the speed of the tools, and the in vivovalidation data that these models can provide, will clearly helpdefinition of disease biology and high-quality target validation.Enhanced target selection will lead to the more efficacious andless toxic therapeutic compounds of the future.
Leading experts in the field provide detailed accounts of modelorganism research that have impacted on specific therapeutic areasand they examine state-of-the-art applications of model systems,describing real life applications and their possible impact in thefuture.
This book will be of interest to geneticists, bioinformaticians,pharmacologists, molecular biologists and people working in thepharmaceutical industry, particularly genomics.
Autor*in
Pamela M. Carroll
Themen in »Model Organisms in Drug Discovery«
Animal Science & Zoology Biotechnologie Biotechnologie i. d. Biowissenschaften Biotechnology Biowissenschaften Cell & Molecular Biology Comparative Biology (Botany & Zoology) Life Sciences Vergleichende Biologie ( Zoologie u. Botanik) Zell- u. Molekularbiologie Zoologie
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"...an invaluable resource for an researcher in the academic orprivate sector...essential for any graduate level course..." (DrugDiscovery Today, Vol 9(7), April 2004)
"...summarised the major organisms of use in this area togetherwith their relative strengths and weaknesses..." (British Societyof Cell Biology Newsletter, Summer 2004)
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