Chiral Chromatography
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Beschreibung
Chiral Chromatography Thomas E. Beesley Advanced SeparationTechnologies Inc., Whippany, New Jersey, USA Raymond P. W. ScottChemistry Department, Georgetown University, Washington DC, USA andChemistry Department, Birkbeck College, University of London, UKAnalytical techniques based on separation processes, such aschromatography and electrophoresis, are finding a growing range ofapplications in chemical, pharmaceutical and clinical laboratories.The Wiley Separation Science Series provides the analyst in theselaboratories with well-focused books covering individualtechniques, so that they can be applied more efficiently andeffectively to contemporary analytical problems. The differentenantiomers of a drug can exhibit widely different physiologicalactivity in degree and nature. As a result, the separation andidentification of enantiomers is now a very important analyticalproblem and chiral chromatography is the natural technique to applyto the resolution of such mixtures. Chiral Chromatography providesthe reader with a basic understanding of the nature ofchromatographic separations and relates the principles specificallyto the separation of enantiomers. The following information isincluded:
* chiral separations involving both gas and liquidchromatography
* descriptions of the apparatus used for both techniques
* detailed discussion on the retention mechanism that results inchiral selectivity
* the structure and synthesis of a wide range of chirally activestationary phases used in both gas and liquid chromatography
* preparative applications for large scale purification ofenantiomers
* applications of capillary electrophoresis and capillaryelectrochromatography.
In addition to the above, a large number of examples of theseparation of both commercially and physiologically interestingchiral mixtures are given, as is a detailed discussion on themechanism of selectivity of each example. Thomas Beesley wasfounder and is the CEO for a leading manufacturer of chiralstationary phases and has published papers on TLC, HPLC and chiralseparations involving cyclodextrins. He has also coauthored paperswith Daniel W. Armstrong, an expert on modern cyclodextrin columns.Raymond Scott has worked in the field of separation science forover 40 years and has contributed extensively to the development ofboth gas and liquid chromatography publishing over 160 papers onthe subjects.
Autor*in
Thomas E. Beesley
Themen in »Chiral Chromatography«
Chemie Chemische Analyse Chemistry Chiralität (Chemie) Chromatographie Chromatographie / Trennverfahren Chromatography / Separation Techniques Industrial Chemistry Technische u. Industrielle Chemie