Selection Bias and Covariate Imbalances in Randomized Clinical Trials
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Beschreibung
Selection bias can, and does, occur, even in randomized clinicaltrials. Steps need to be taken in order to ensure that this doesnot compromise the integrity of clinical trials; hence"Selection Bias and Covariate Imbalances in RandomizedClinical Trials" offers a comprehensive treatment of thesubject and the methodology involved. This book:
* Provides an overview of the hierarchy of study designs, andjustifies the position of randomised trials at the top of thishierarchy.
* Discusses the strengths and defects of randomisation, andprovides real evidence to justify concern regarding itsdefects.
* Outlays the damaging consequences that selection bias causeswhen it does occur.
* Considers courses of action that can be taken to manage/contain the problem.
* Presents methods that can be used to detect selection bias inrandomised trials, and methods to correct for selection bias.
* Concludes by providing a comprehensive plan for managingbaseline imbalances and selection bias in randomised trials, andproposing open problems for future research.
Illustrated with case studies, this book introducesgroundbreaking ideas and research that will be invaluable toresearchers and practitioners who design and analyse clinicaltrials. It will also be of interest to graduate students within thefield of biostatistics.
Autor*in
Vance Berger
Themen in »Selection Bias and Covariate Imbalances in Randomized Clinical Trials«
Biostatistics Biostatistik Medical Science Medizin Pharmacology & Pharmaceutical Medicine Pharmakologie u. Pharmazeutische Medizin Statistics Statistik
Stimmen zu »Selection Bias and Covariate Imbalances in Randomized Clinical Trials«
"...the author presents a provocative discussion ofrandomization and TORSB." (Computational Statistics, January2008)
"...recommended to all practitioners and researchers in thefield of clinical trials..." (Biometrics, December2005)
" ... informative and interesting to read"(Phamaceutical Statistics Volume 5:2)
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