Database Annotation in Molecular Biology

Beschreibung

Two factors dominate current molecular biology: the amount of rawdata is increasing very rapidly and successful applications inbiomedical research require carefully curated and annotateddatabases. The quality of the experimental data -- especiallynucleic acid sequences -- is satisfactory; however, annotationsdepend on features inferred from the data rather than measureddirectly, for instance the identification of genes in genomesequences. It is essential that these inferences are as accurate aspossible and this requires human intervention. With the recognition of the importance of accurate databaseannotation and the requirement for individuals with particularconstellations of skills to carry it out, annotators are emergingas specialists within the profession of bioinformatics. This bookcompiles information about annotation -- its current status, whatis required to improve it, what skills must be brought to bear ondatabase curation and hence what is the proper training forannotators. The book should be essential reading for all people working onbiological databases, both biologists and computer scientists. Itwill also be of interest to all users of such databases, includingmolecular biologists, geneticists, protein chemists, clinicians anddrug developers.

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Arthur M. Lesk

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Bioinformatics & Computational Biology Bioinformatik Bioinformatik u. Computersimulationen in der Biowissenschaften Biowissenschaften Life Sciences Molekularbiologie

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