Cross-over Trials in Clinical Research

Beschreibung

Cross-over trials are an important class of design used in thepharmaceutical industry and medical research, and their usecontinues to grow. Cross-over Trials in Clinical Research, SecondEdition has been fully updated to include the latest methodologyused in the design and analysis of cross-over trials. It includesmore background material, greater coverage of important statisticaltechniques, including Bayesian methods, and discussion of analysisusing a number of statistical software packages. * Comprehensive coverage of the design and analysis of cross-overtrials. * Each technique is carefully explained and the mathematics is keptto a minimum. * Features many real and original examples, taken from the author'svast experience. * Includes discussion of analysis using SAS, S-Plus and, GenStat,StatXact and Excel. * Written in a style suitable for statisticians and physiciansalike. * Computer programs to accompany the examples in the book can bedownloaded from the Web Primarily aimed at statisticians and researchers working in thepharmaceutical industry, the book will also appeal to physiciansinvolved in clinical research and students of medicalstatistics.

Autor*in

Stephen S Senn

Themen in »Cross-over Trials in Clinical Research«

Biometrie Biostatistics Biostatistik Mathematik / Wahrscheinlichkeitstheorie, Statistik Statistics Statistik

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"...clearly written...mode of presentation is veryeffective...I recommend this book as a useful resource..."(Journal of the American Statistical Association, December2004) "The book by Senn was the very first volume in Wiley's excellentseries, "Statistics in Practice". Here, 10 years later, it isnow the first of the books in that series to reappear in a secondaddition." (Technometrics, May 2004) "...well structured and easy to read...incredibly useful..."(Applied Clinical Trials, December 2002) "...an excellent reference source and is easily readable."(The Statistician) "...explanation are kept as non-technical as possible, althoughthey do not lack statistical rigour...well worth reading..."(Pharmaceutical Statistics, Vol 2, 2003) "...the main additions can be seenas ...adding to the arguments for the author's viewon carryover affects..." (Clinical Trials, No.12004)
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