Prediction of Protein Structures, Functions, and Interactions

Beschreibung

The growing flood of new experimental data generated by genomesequencing has provided an impetus for the development of automatedmethods for predicting the functions of proteins that have beendeduced by sequence analysis and lack experimentalcharacterization. Prediction of Protein Structures, Functions and Interactionspresents a comprehensive overview of methods for prediction ofprotein structure or function, with the emphasis on theiravailability and possibilities for their combined use. Methods ofmodeling of individual proteins, prediction of their interactions,and docking of complexes are put in the context of predicting geneontology (biological process, molecular function, and cellularcomponent) and discussed in the light of their contribution to theemerging field of systems biology. Topics covered include: * first steps of protein sequence analysis and structureprediction * automated prediction of protein function from sequence * template-based prediction of three-dimensional proteinstructures: fold-recognition and comparative modelling * template-free prediction of three-dimensional proteinstructures * quality assessment of protein models * prediction of molecular interactions: from small ligands tolarge protein complexes * macromolecular docking * integrating prediction of structure, function, andinteractions Prediction of Protein Structures, Functions and Interactionsfocuses on the methods that have performed well in CASPs, and whichare constantly developed and maintained, and are freely availableto academic researchers either as web servers or programs for localinstallation. It is an essential guide to the newest, best methodsfor prediction of protein structure and functions, for researchersand advanced students working in structural bioinformatics, proteinchemistry, structural biology and drug discovery.

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Janusz Bujnicki

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Biochemie Biochemie u. Chemische Biologie Biochemistry (Chemical Biology) Bioinformatics & Computational Biology Bioinformatik Bioinformatik u. Computersimulationen in der Biowissenschaften Biowissenschaften Chemie Chemistry Life Sciences Proteomics

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