Genetic Effects on Environmental Vulnerability to Disease
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Beschreibung
Much research has attempted to show direct linear relations betweengenes and disorder. However, scientists have been discouraged byinconsistent findings based on this simple gene-phenotype approach.The alternative approach is to incorporate information about theenvironment. A gene-environment interaction approach assumes thatenvironmental pathogens cause disorder, whereas genes influencesusceptibility to environmental pathogens.
This book brings together contributions from experts frommultiple disciplines who discuss:
* How epidemiological cohort studies can better integratephysiological (mechanistic) measures;
* How best to characterise subjects' vulnerability versusresilience by moving beyond single genetic polymorphisms;
* How gene hunters can benefit from recruiting samples selectedfor known exposures;
* How environmental pathogens can be used as tools for genehunting;
* How to deal with potential spurious (statistical) interactions,and
* How genes can help explain fundamental demographic propertiesof disorders (e.g. sex distribution, age effects).
Autor*in
Michael Rutter
Themen in »Genetic Effects on Environmental Vulnerability to Disease«
Biowissenschaften Epidemiologie Genetics Genetik Life Sciences Medical Science Medical Statistics & Epidemiology Medizin Medizinische Statistik u. Epidemiologie Psychiatrie Psychiatry Statistics Statistik