The Bioinorganic Chemistry of Chromium

Beschreibung

Chromium exists in nature as complexes of two stable oxidation states - trivalent chromium(III) and hexavalent chromium(VI). Although chromium(VI) is a well known human toxin and potential carcinogen, the effects of chromium(III) on the body are less well known. Chromium(III) has been proposed to be required in trace amounts for proper sugar and lipid metabolism in humans, and its deficiency has been proposed to result in symptoms similar to diabetes. Chromium(III) compounds have been popular nutraceuticals, claimed to aid weight loss and muscle mass enhancement. However, the nutritional essentialness of chromium(III) has been questioned, while chromium(III) has been proposed to serve as a possible therapeutic agent to treat diabetes and insulin resistance. The use of chromium(III) compounds as nutraceutical or therapeutic agents has raised questions about the toxicity of these compounds. The Bioinorganic Chemistry of Chromium takes a critical look at what the biochemical data indicate about chromium's role in the body and the biological mechanisms of its potential toxicology. Topics covered include: The Bioinorganic Chemistry of Chromium is an important contribution to the bioinorganic and trace element biochemical fields which will find a place on the bookshelves of bioinorganic chemists, biochemists, inorganic chemists, toxicologists, nutritionists and regulatory affairs professionals. * what do we know about the biochemical roles and mechanisms of chromium? * the current status of chromium as defined by government agencies or public foundations * is chromium an essential element in the mammalian diet? * is chromium(III) effective as a nutraceutical, a therapeutic agent, and as a supplement in animal feed? * what is the biochemistry behind the potential toxicology of chromium(III): the mechanisms of metabolism and effect on cell signalling? * what are the current chromium(III) policies and positions from regulatory agencies?
Chromium exists in nature as complexes of two stable oxidation states - trivalent chromium(III) and hexavalent chromium(VI). Although trivalent chromium is required in trace amounts for sugar and lipid metabolism in humans and its deficiency may cause a disease called chromium deficiency; hexavalent chromium is toxic and carcinogenic. As chromium compounds were used in dyes and paints and the tanning of leather, these compounds are often found in soil and groundwater at abandoned industrial sites, now needing environmental cleanup and remediation. The Bioinorganic Chemistry of Chromium: From Biochemistry to Environmental Toxicology takes a critical look at what the biochemical data indicate about chromium's role in the body and the biological mechanisms of its toxicology. Topics covered include: * What do we know about the biochemical roles and mechanisms of chromium? * Is chromium an essential element in the mammalian diet? * Is chromium(III) effective as a nutraceutical, a therapeutic agent, and as a supplement in animal feed? * What is the biochemistry behind the toxicology of chromium(III) and chromium(VI):the mechanisms of metabolism, genetic and epigenetic effects, and disruption of cell signalling? * What are the current chromium(VI) policies and positions from regulatory agencies? The Bioinorganic Chemistry of Chromium: From Biochemistry to Environmental Toxicology is an important contribution to the bioinorganic and trace element biochemical fields which will find a place on the bookshelves of bioinorganic chemists, biochemists, inorganic chemists, toxicologists, nutritionists and regulatory affairs professionals.

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John Vincent

Themen in »The Bioinorganic Chemistry of Chromium«

Bioanorganische Chemie Biochemie Biochemie u. Chemische Biologie Biochemistry (Chemical Biology) Bioinorganic Chemistry Chemie Chemistry Toxicology Toxikologie

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