G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and biologists will find essential information in this comprehensive reference.
Annette Gilchrist
Biowissenschaften Chemie Chemistry Drug Discovery & Development Life Sciences Medical Science Medizin Pharmacology & Pharmaceutical Medicine Pharmakologie Pharmakologie u. Pharmazeutische Medizin Proteine u. Makromoleküle Proteins & Macromolecules Wirkstoffforschung u. -entwicklung
"Additionally, the presentation of the fundamental concepts of GPCR biology by the authors, who are recognized experts in the GPCR field, is likely to be appreciated by students of pharmacology. . . This is a unique resource for navigating the field of GPCR research." (Doody's, 23 September 2011)
"The first emerge as promising therapeutic targets and, as understanding of their pharmacology advances, new treatments for various diseases can be uncovered." (ChemMedChem, 1 February 2011)
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