Instrumental Analysis of Intrinsically Disordered Proteins

Beschreibung

Instrumental techniques for analyzing intrinsically disorderedproteins The recently recognized phenomenon of protein intrinsic disorderis gaining significant interest among researchers, especially asthe number of proteins and protein domains that have been shown tobe intrinsically disordered rapidly grows. The first reference totackle this little-documented area, Instrumental Analysis ofIntrinsically Disordered Proteins: Assessing Structure andConformation provides researchers with a much-needed,comprehensive summary of recent achievements in the methods forstructural characterization of intrinsically disordered proteins(IDPs). Chapters discuss: * Assessment of IDPs in the living cell * Spectroscopic techniques for the analysis of IDPs, including NMRand EPR spectroscopies, FTIR, circular dichroism, fluorescencespectroscopy, vibrational methods, and single-molecule analysis * Single-molecule techniques applied to the study of IDPs * Assessment of IDP size and shape * Tools for the analysis of IDP conformational stability * Mass spectrometry * Approaches for expression and purification of IDPs With contributions from an international selection of leadingresearchers, Instrumental Analysis of Intrinsically DisorderedProteins: Assessing Structure and Conformation fills animportant need in a rapidly growing field. It is required readingfor biochemists, biophysicists, molecular biologists, geneticists,cell biologists, physiologists, and specialists in drug design anddevelopment, proteomics, and molecular medicine with an interest inproteins and peptides.

Autor*in

Vladimir Uversky

Themen in »Instrumental Analysis of Intrinsically Disordered Proteins«

Analytical Chemistry Analytische Chemie Biochemie Biochemie u. Chemische Biologie Biochemistry (Chemical Biology) Biowissenschaften Cell & Molecular Biology Chemie Chemistry Life Sciences Proteine Zell- u. Molekularbiologie

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"With contributions from an international selection of leading researchers, this book fills an important need in a rapidly growing field. It is required reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, physiologists, and specialists in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides." (Anticancer Research, 1 August 2010)
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