Vanilloid Receptor TRPV1 in Drug Discovery
Targeting Pain and Other Pathological Disorders
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Beschreibung
Examines the emerging therapeutic role of TRPV1
TRPV1 is considered an integrator of noxious stimuli andtherefore may be at a crossroads for pain transmission pathways.Because of its potential for managing multiple pain types,including osteoarthritis, chronic low back pain, neuropathic pain,and cancer pain, some consider it "the holy grail" of painmanagement. This dedicated reference summarizes available datarelated to the potential therapeutic utility for TRPV1 ligands.
With contributions from many of the world's leading experts onTRP channels, Vanilloid Receptor TRPV1 in Drug Discoverycovers the important TRPV1 target for drugs to treat painfulconditions such as inflammation, arthritis, and cancer pain. Thebook discusses:
* Recent advances in biology, chemistry, and pharmacology at boththe preclinical and clinical stage of the dynamic area of TRPV1drug discovery research
* The potential for drugs targeting TRPV1 in painful conditionssuch as inflammation, arthritis, and cancer
* The development of analgesic drugs
* Other applications for TRPV1, including the treatment ofrespiratory disease and diabetes
Featuring data relevant to the therapeutic potential of TRPV1and the medicinal chemistry involved in designing TRPV1antagonists, Vanilloid Receptor TRPV1 in Drug Discovery is akey tool for researchers in the pharmaceutical industry andacademia involved in pain, ion channels, and analgesic drugdevelopment.
Autor*in
Arthur Gomtsyan
Themen in »Vanilloid Receptor TRPV1 in Drug Discovery«
Biowissenschaften Chemie Chemistry Drug Discovery & Development Life Sciences Medical Science Medizin Neuroscience Neurowissenschaften Pharmacology & Pharmaceutical Medicine Pharmakologie u. Pharmazeutische Medizin Pharmazeutische Chemie Wirkstoffforschung Wirkstoffforschung u. -entwicklung