Lead Generation Approaches in Drug Discovery
Buch in deiner Nähe kaufen
Beschreibung
An integrated overview of modern approaches to leaddiscovery
Lead generation is increasingly seen as a distinct andsuccess-determining phase of the drug discovery process. Overrecent years, there have been major advances in the understandingof what constitutes a good lead compound and how to improve thechances of finding such a compound. Written by leading scientistsand established opinion leaders from industry and academia, thisbook provides an authoritative overview of the field, as well asthe theory, practice, and scope, of the principal LeadGeneration Approaches in Drug Discovery, including:
* The evolution of the lead discovery process, key concepts,current challenges, and future directions
* Strategies and technologies driving the high-throughputscreening (HTS) approach to lead discovery, including the shiftingparadigms in the design of compound collections and best practicein the hit confirmation process
* Knowledge-based in silico or "virtual" screening
* Theory and practice of the fragment-based approach to leaddiscovery
* The opportunities and challenges presented by multi-target drugdiscovery (MTDD)
* De novo design of lead compounds and new approaches toestimating the synthetic accessibility of de novo-designedmolecules
* The impact of natural products on drug discovery, and potentialof natural product-like compounds for exploring regions ofbiologically relevant chemical space
* Using early screening of hits and leads for metabolic,pharmacokinetic, and toxicological liabilities to reduce attritionduring the later phases of drug discovery
* The utility of parallel synthesis and purification in leaddiscovery
With each topic supported by numerous case studies, this isindispensable reading for researchers in industry and academia whowish to keep up to date with the latest strategies and approachesin drug discovery.
Autor*in
Zoran Rankovic
Themen in »Lead Generation Approaches in Drug Discovery«
Chemie Chemistry Computational Chemistry & Molecular Modeling Computational Chemistry u. Molecular Modeling Drug Discovery & Development Medical Science Medizin Pharmacology & Pharmaceutical Medicine Pharmakologie u. Pharmazeutische Medizin Wirkstoffforschung Wirkstoffforschung u. -entwicklung
Stimmen zu »Lead Generation Approaches in Drug Discovery«
"The book provides a comprehensive overview of many aspects of thelead generation process . . . The book delivers a good introductionto the process of lead generation for novice researchers. It isalso useful for more experienced scientists to update theirknowledge and/or to identify some new details." (ChemMedChem,October 2010)
"This volume is recommended to chemists and biologists who wishto learn about the practice of high throughput screening and aboutthe concepts involved in making the method a successful route todrug discovery." (Journal of Medicinal Chemistry, 2010)"Eachchapter provides a comprehensive overview of one aspect of the leadgeneration process. To get more indepth knowledge, extensivereferences including recent publications are given."(ChemMedChem, 2010)
()