Evaluation of Drug Candidates for Preclinical Development

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Emphasizes the integration of major areas of drug discovery andtheir importance in candidate evaluation It is believed that selecting the "right" drug candidate fordevelopment is the key to success. In the last decade,pharmaceutical R&D departments have integrated pharmacokineticsand drug metabolism, pharmaceutics, and toxicology into early drugdiscovery to improve the assessment of potential drug compounds.Now, Evaluation of Drug Candidates for Preclinical Developmentprovides a complete view and understanding of whyabsorption-distribution-metabolism-excretion-toxicology (ADMET)plays a pivotal role in drug discovery and development. Encompassing the three major interrelated areas in whichoptimization and evaluation of drug developability is mostcritical--pharmacokinetics and drug metabolism, pharmaceutics,and safety assessment--this unique resource encouragesintegrated thinking in drug discovery. The contributors to thisvolume: * Cover drug transporters, cytochrome P-450 and drug-druginteractions, plasma protein binding, stability, drug formulation,preclinical safety assessment, toxicology, and toxicokinetics * Address developability issues that challenge pharma companies,moving beyond isolated experimental results * Reveal connections between the key scientific areas that arecritical for successful drug discovery and development * Inspire forward-thinking strategies and decision-makingprocesses in preclinical evaluation to maximize the potential ofdrug candidates to progress through development efficiently andmeet the increasing demands of the marketplace Evaluation of Drug Candidates for Preclinical Development servesas an introductory reference for those new to the pharmaceuticalindustry and drug discovery in particular. It is especially wellsuited for scientists and management teams in small- to mid-sizedpharmaceutical companies, as well as academic researchers andgraduate students concerned with the practical aspects related tothe evaluation of drug developability.

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Chao Han

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Chemie Chemistry Drug Discovery & Development Medical Science Medizin Pharmacology & Pharmaceutical Medicine Pharmakologie u. Pharmazeutische Medizin Pharmazeutische Chemie Toxicology Toxikologie Wirkstoffforschung u. -entwicklung

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"This is a useful reference source for those new to, or aspiring to join the pharmaceutical industry, for academics, and for students of pharmacy and pharmaceutical sciences." (Chromatographia, 1 December 2010) "In conclusion, the book brings the areas of ADME, toxicology and pharmaceutical science together to describe the approaches used to select safe compounds with the required pharmacokinetic and physiochemical properties for progressing into clinical development". (British Toxicology Society, Winter 2010)
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