Organic Azides

Beschreibung

Organic azides are energy-rich and flexible intermediates for organic synthesis. They have found a variety of uses as reagents for the synthesis of heterocycles, as a "masked" amino function in natural compound synthesis, as the most important precursors of nitrenes, and as detonators, blowing agents for polymers, and functional groups in pharmaceuticals. In the past decade completely new perspectives have been developed for the use of azides in peptide chemistry, combinatorial chemistry, and heterocyclic synthesis. Organic azides have assumed an important position at the interfaces between chemistry, biology, medicine, and materials science. Organic Azides: Syntheses & Applications is an essential guide to the use and applications of this important class of compounds. Topics covered include the following aspects: * synthesis and safety of azides * the chemistry of vinyl azides * small rings by azide chemistry * rearrangement reactions of azides * radical chemistry with azides * cycloaddition reactions with azides * click chemistry with azides * dipolar cycloaddition reactions in peptide chemistry * photochemistry of azides, and the azide/nitrene interface * organometallic chemistry with azides * applications in materials science, including azides in high energy materials, polymers and combinatorial chemistry * applications in bioorganic chemistry, including azides in carbohydrate chemistry, natural products synthesis and Staudinger ligation Organic Azides: Syntheses & Application is a comprehensive, authoritative and up-to-date guide to these important reagents for organic chemists, drug discovery researchers, materials scientists and those interested in the chemistry of natural products.
* Most current state-of-the-art overview of this important class of compounds, encompassing many new and emerging applications * The number of articles on organic azides continues to increase tremendously; on average, there are more than 1000 new publications a year * Covers basic chemistry as well as state-of-the-art applications in life science and materials science * World-ranked authors describe their own research in the wider context of azide chemistry * Includes a chapter on safe synthesis and handling (azides can decompose explosively)

Autor*in

Stefan Bräse

Themen in »Organic Azides«

Chemie Chemistry Drug Discovery & Development Natural Products Naturstoffchemie Organic Chemistry Organische Chemie Polymer Science & Technology Polymer Synthesis Polymersynthese Polymerwissenschaft u. -technologie Wirkstoffforschung u. -entwicklung

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"This book is timely and important - the first devoted entirely to azides to appear in 26 years. . . The editors are to be congratulated for attracting so many experts to produce an excellent work in a timely fashion that should find a place in all laboratories." (JACS, 2010)
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