G Protein-coupled Receptors
Molecular Pharmacology
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Beschreibung
G protein-coupled receptors (GPCRs) are membrane proteins thattransduce a vast array of extracellular signals into intracellularreactions ranging from cell-cell communication processes tophysiological responses. They play an important role in a varietyof diseases from cancer and diabetes, to neurodegenerative,inflammatory and respiratory disorders. GPCRs are therefore ofutmost interest in drug development: over half of all prescriptiondrugs currently on the market act by targeting these receptorsdirectly or indirectly.
G Protein-coupled Receptors: MolecularPharmacology provides a clear summary of the currentknowledge in this fast-evolving field. The book sets out with anintroduction to signalling molecules and their receptors, and anoverview of the technical approaches used to investigate theseinteractions. Structural, functional and especially pharmacologicalaspects of GPCRs are then discussed in more detail and muchattention is devoted to the analysis and interpretation ofexperimental data. The now widespread use of recombinant cell lies,receptor mutants and related artifices in drug research iscritically evaluated. Special attention is also devoted to topicalbut often poorly understood concepts, such as insurmountableantagonism, inverse agonism and allosteric interactions.
By combining general information with the major state-of-the-artconcepts in GPCR-research, this outstanding book equipsthe reader with the necessary background for understanding andcritically evaluating the current literature.
Written by two experts from academia and industry, GProtein-coupled Receptors: Molecular Pharmacology offers aunique view of academic and applied approaches aiming to reveal newideas in pharmaceutical research.
The book is of interest to anyone involved in drug developmentand preclinical research and those who need to function withinmulti-disciplinary teams in the pharmaceutical industry: frominvestigators to product managers or clinicians who seek to have abroad mechanistic understanding of drug-receptor interactions. Itis also an invaluable resource for final year undergraduate andpostgraduate students in pharmacology and cell and molecularbiology.
Autor*in
Georges Vauquelin
Themen in »G Protein-coupled Receptors«
Biowissenschaften Cell & Molecular Biology Chemie Chemistry Life Sciences Medical Science Medizin Molekularbiologie Pharmaceutical & Medicinal Chemistry Pharmacology & Pharmaceutical Medicine Pharmakologie Pharmakologie u. Pharmazeutische Medizin Pharmazeutische u. Medizinische Chemie Zell- u. Molekularbiologie