Gap Junction-Mediated Intercellular Signalling in Health and Disease

Beschreibung

Gap junctions are key elements in communication between cells inmulticellular organisms. It is clear that their activityis essential for normal embryonic development and normal functionin adult organs, although the individual roles of the proteins thatform the channels (connexins) are not yet fully understood. The last few years have seen considerable progress in this fieldand exciting new issues concerning gap junctional intercellularcommunication are being raised. Perturbed gap junctionactivity is beginning to be linked to certain pathologies,e.g. mutations in the major connexin of the heart have beenfound in human patients suffering from visceroatrial heterotaxiasyndrome and mutations in the gene encoding another connexin havebeen found in patients with Charcot-Marie-Tooth disease. This book is the first to highlight the recent progress inunderstanding gap junction structure and to discuss the specificroles of individual connexins. It features contributions from aninterdisciplinary group of experts who review the role of gapjunctions in the heart, the retina and lens, the auditory system,the reproductive system, and in cell proliferation and cancer. The book will appeal to people interested in cell andmolecular biology, embryonic development, neurobiology, cardiology,gynaecology and oncology.

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Gail Cardew

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Biowissenschaften Cell & Molecular Biology Life Sciences Medical Science Medizin Zell- u. Molekularbiologie Zellkommunikation

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"....this book in my opinion, is necessary to keep abreast in this rapidly progressing field.....", , , Cell Biology International#
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