Biotransformation and Metabolite Elucidation of Xenobiotics

Beschreibung

An Up-To-Date Guide on the Exciting Possibilities of Metabolite Identification in Drug Discovery Over the years, metabolite identification and characterization have progressed to the point where they now play a major role in drug discovery and development. In particular, the metabolite elucidation of xenobiotics has been instrumental in increasing the success rate of selected drug candidates that hold the most promise for being safe and effective. To explore the analytical possibilities present in this field, this book provides in-depth coverage on designing, developing, and advancing metabolite characterization for drug research. It discusses topics ranging from how and when to perform metabolite identification and characterization to perspectives on regulatory requirements. Biotransformation and Metabolite Elucidation of Xenobiotics also: * Excellent primer and updated chapter on human biotransformation by Dr. Parkinson * Supplies up-to-date details on the tools and techniques needed to perform metabolite identification * Presents modern approaches and strategies to deal with metabolite characterization, using techniques such as LC-MS , H-D exchange, stable isotopes, and LC-MS-NMR * Provides case studies to help improve the decision-making process in the structural modification of drug candidates-enhancing metabolic stability, improving PK properties, and reducing toxicity * Includes FDA guidelines such as "Safety Testing of Drug Metabolites" Giving direction and focus to improving drug discovery techniques, Biotransformation and Metabolite Elucidation of Xenobiotics is a pioneering guide rich in content that displays the verve of experts passionate about their work. It carefully and systemically approaches educating researchers and students to instill them with a better understanding on how to apply the principles of metabolite identification to create drugs that are safer, more targeted, and able to perform to the highest standards.
The goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity. The book consists of 8 chapters; it first provides an introduction on biotransformation of xenobiotics, and then presents modern approaches and strategies for dealing with metabolite characterization, using tools such as LC-MS, H-D exchange, stable isotopes LC-MS-NMR, and radiolabeled compounds. Also, strategies for dealing with reactive intermediates in drug discovery and development are presented as well as case studies on improving the decision-making process in the structural modification of drug candidates. The last chapter discusses the regulatory perspectives of safety testing of drug metabolites and why, how, and when to test their safety.

Autor*in

Ala F. Nassar

Themen in »Biotransformation and Metabolite Elucidation of Xenobiotics«

Analytical Chemistry Analytische Chemie Biochemie Biochemistry Biowissenschaften Chemie Chemistry Drug Discovery & Development Life Sciences Wirkstoffforschung u. -entwicklung

Stimmen zu »Biotransformation and Metabolite Elucidation of Xenobiotics«

"Contributors mostly from pharmaceutical companies provide a systematic introduction to characterizing metabolites, which has become an important element in drug discovery. They write for scientists involved in designing, developing, and advancing metabolic characterizations for drug discovery and development, and for researchers and students in fields that might call for such characterizations." (Book News Inc., February 2011)
()

Details

Link teilen