ABC Transporters and Multidrug Resistance
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Beschreibung
A comprehensive review of the most current scientific researchon ABC transporters and multidrug resistance
ATP-binding cassette transporter genes (ABC transporters) areknown to play a crucial role in the development of multidrugresistance (MDR). MDR is the ability of pathologic cells, such astumors, to withstand chemicals designed to target and destroy suchcells. In MDR, patients who are on medication eventually developresistance to not only the drug they are taking, but to severaldifferent types of drugs.
ABC Transporters and Multidrug Resistance offers anessential resource for pharmaceutical researchers who are workingto discover drugs to counteract multidrug resistance in diseasessuch as cancer. In one comprehensive volume, this book contains acollection of the most current knowledge on the involvement of ABCtransporters in drug transport and resistance.
This comprehensive volume provides an overview on thedescription of the structure, the genome, normal tissue expression,physiological aspect, and mechanism of action of the ABC protein.The expert contributors explore the expression, detection, andimplications of ABC proteins in hematological malignancies andsolid tumors and ABC proteins and pathogenic microorganisms. Thisvolume also explains MDR modulation through inhibition of ABCtransporters and the design of inhibitors and mechanism of action.In addition, the book offers essential information on thebiological and clinical aspect of multidrug resistance.
Autor*in
Ahcène Boumendjel
Themen in »ABC Transporters and Multidrug Resistance«
Biowissenschaften Cell & Molecular Biology Chemie Chemistry Life Sciences Medical Science Medizin Pharmaceutical & Medicinal Chemistry Pharmacology & Pharmaceutical Medicine Pharmakologie u. Pharmazeutische Medizin Pharmazeutische Chemie Pharmazeutische Medizin Pharmazeutische u. Medizinische Chemie Zell- u. Molekularbiologie
Stimmen zu »ABC Transporters and Multidrug Resistance«
"The book is both interesting for both novice and experiencedresearches in the field." (ChemMedChem, July 2010)
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