Preclinical Development Handbook

Beschreibung

A clear, straightforward resource to guide you through preclinicaldrug development Following this book's step-by-step guidance, you can successfullyinitiate and complete critical phases of preclinical drugdevelopment. The book serves as a basic, comprehensive reference toprioritizing and optimizing leads, dose formulation, ADME,pharmacokinetics, modeling, and regulations. This authoritative,easy-to-use resource covers all the issues that need to beconsidered and provides detailed instructions for current methodsand techniques. Each chapter is written by one or more leading experts in thefield. These authors, representing the many disciplines involved inpreclinical toxicology screening and testing, give you the toolsneeded to apply an effective multidisciplinary approach. The editorhas carefully reviewed all the chapters to ensure that each one isthorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may beencountered and their solutions. The authors also set forth thelimitations of various methods and techniques used in determiningthe safety and efficacy of a drug during the preclinicalstage. This publication should be readily accessible to all pharmaceuticalscientists involved in preclinical testing, enabling them toperform and document preclinical safety tests to meet all FDArequirements before clinical trials may begin.

Autor*in

Shayne Cox Gad

Themen in »Preclinical Development Handbook«

Chemie Chemistry Drug Discovery & Development Medical Science Medizin Pharmacology & Pharmaceutical Medicine Pharmakologie u. Pharmazeutische Medizin Pharmazeutische Medizin Toxicology Toxikologie Wirkstoffforschung u. -entwicklung

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"A valuable source of reference and one that I'm sure will get regular use. The diversity of topics should appeal to a variety of pharmaceutical scientists." (The British Toxicology Newsletter, Winter 2008)
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